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Nat Commun. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Modulation of constitutive collagen gene expression by lipid peroxidation. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. J Gastroenterol Hepatol. 2000 Sep 29; 275(39):30597-604. J Gastroenterol Hepatol. Proc Natl Acad Sci U S A. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. 2005 Mar; 39(3):181-8. 2003 Feb; 124(2):445-58. J Clin Invest. FASEB J. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Int J Biochem Cell Biol. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. This graph shows the total number of publications by year. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. 2012; 7(4):e34218. Hepatology. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. J Gastroenterol Hepatol. Kenji Fujiwara, MD, PhD. 2006 May; 130(6):1564-72. J Exp Med. 1999 09; 277(3):G671-7. Am J Physiol. 1979 Sep-Oct; 52(5):449-54. Hepatology. 2011 Jul; 179(1):189-98. 2000 Mar; 15 Suppl:D20-5. Clin Gastroenterol Hepatol. 2007 Jun 15; 462(2):266-72. 2015 Dec; 149(7):1784-93. Hepatology. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. 2009 Jul; 50(1):185-97. Hepatology. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Promising Therapy Candidates for Liver Fibrosis. Liver Transpl Surg. David has 2 jobs listed on their profile. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 1998 May; 114(5):1035-45. 1997 Jan 17; 272(3):1753-60. 2003 Jul 15; 76(1):28-37. 2012 Nov; 67(11):1357-64. Vuori will TLR4 enhances TGF-beta signaling and hepatic fibrosis. Proc Natl Acad Sci U S A. A logical approach to the patient with jaundice. 2001 Aug 17; 89(4):351-6. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. Korean J Hepatol. 2020 Apr; 4(4):606-626. Front Physiol. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Hepatology. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. 2001 Jun; 280(6):G1178-86. 2014 Oct; 27(5):413-25. 2001 Apr 10; 103(14):1920-7. Aliment Pharmacol Ther. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. 2017 10 10; 114(41):10808-10809. 2002 Sep; 123(3):877-8. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Gastroenterology. PLoS One. 2011 May; 53(5):1730-41. Methods Enzymol. 2009; 44 Suppl 19:1-7. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. A method for in vitro DNase I footprinting analysis on supercoiled templates. 2014 Apr 29; 63(16):1626-33. 2001 Jul 10; 104(2):221-6. 2013 Nov; 9(11):737-9. Clin Gastroenterol Hepatol. Hepatology. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. People who share similar concepts with this person. 2017 01; 65(1):78-88. Surgery. 2009 Jan; 49(1):6-8. Nucleic Acids Res. 2000; 32(1 Suppl):32-8. 2015 Nov-Dec; 49 Suppl 1:S69-73. 2021 05; 134:105933. 1994 Sep; 14 (9):5950-60. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Gastroenterology. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective 1994 Sep; 3(9):1695-7. 2020 Feb; 21(2):89-98. Biofactors. PLoS One. Am J Gastroenterol. 2001 Nov; 34(5):953-63. Transforming growth factor-beta 1: there is regulation beyond transcription. Proud to be part of UC San Diego and UC San Diego Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gene Expr. Front Mol Biosci. Hepatol Res. Yang L, Magness ST, Bataller R, Rippe RA. New Developments on the Treatment of Liver Fibrosis. WebDavid Brenner. J Clin Exp Hepatol. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. J Hepatol. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Am J Physiol. Hepatology. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Fibrogenesis Tissue Repair. 2016 Feb 10; 19(2):227-39. 2014 Mar 07; 289(10):7082-7091. 2000 Jul; 33(1):49-58. Gut. 2020; 15(3):e0229445. Gut. Clin Immunol. Hepatology. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Lab Invest. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. The enzymatic defect in variegate prophyria. J Immunol. Nucleic Acids Res. To return to the graph. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Mechanisms of liver fibrosis and its role in liver cancer. Gut. 2020 05; 158(6):1728-1744.e14. Studies with human cultured skin fibroblasts. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. Toxicol Sci. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. 2007 Apr-Jun; 6(2):83-8. 2001 Apr; 120(5):1251-62. J Biol Chem. 2020 Nov 03; 32(5):901. Am J Physiol Gastrointest Liver Physiol. J Gastroenterol Hepatol. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Infect Immun. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. 2009 Mar 03; 106(9):3300-5. Expression of human immunodeficiency virus-1 in human colonic cells. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. 1998 Feb; 2(1):77-102, vi. Cancer Res. 2003 Mar; 37(3):653-64. 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The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. NEK1 mutations in familial amyotrophic lateral sclerosis. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 2020 12; 72(6):2182-2196. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. 1989 May; 8(4):279-85. 2014 Jun 10; 20(17):2854-72. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Interactions between the intestinal microbiome and liver diseases. J Clin Invest. 2006 Jul; 131(1):272-5. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 1998 Sep; 13(S1):S39-S50. 2005 Nov; 29(11 Suppl):102S-109S. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. Hepatology. 2019 Sep 03; 30(3):607. 2018 09; 68(3):918-932. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Hepatology. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Am J Physiol. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. 2011 Jan; 53(1):96-105. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? 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Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Proc Natl Acad Sci U S A. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. 1999; 8(3):151-63. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Adv Second Messenger Phosphoprotein Res. 2014 Jul 21; 5:4451. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. J Clin Invest. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Cell Metab. Gastroenterology. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. Dig Dis. Involvement of death receptor-related signaling pathways. 2019 10; 68(10):1884-1892. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Liver Int. J Clin Invest. Hepatology. 2000 Nov 01; 28(21):4306-16. Hepatology. Hepatology. 2002 Jul; 283(1):C347-57. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. 1990 Nov; 26(11):1011-23. 2001 Aug; 21(3):437-51. 1980 Apr 03; 302(14):765-9. 2000 Nov; 119(5):1399-401. 2006 Aug; 116(8):2058-9. New therapies for hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 1999 Jan 06; 1453(1):161-74. Gut. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. DNA. Am J Physiol Gastrointest Liver Physiol. Cell Death Differ. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Hepatology. Exp Biol Med (Maywood). To see the data as text. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. 2002 Aug; 36(2):315-25. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. 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WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2002 Jul; 283(1):G204-11. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Hepatology. Am J Physiol. 1994 Dec 09; 269(49):30789-97. In Vitro Cell Dev Biol. Biochem Biophys Res Commun. 1997 May; 25(5):1128-35. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Amyotroph Lateral Scler Frontotemporal Degener. 1999 Oct 22; 274(43):30919-26. 1999 Jun; 29(6):1680-9. Nuclear factor-kappaB in the liver: friend or foe? 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Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Mol Pharmacol. 1999 Mar; 31(2):173-9. 2007 Aug; 47(2):307-9. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Int Psychogeriatr. 2013 Feb 01; 12(3):381-2. 2018 12; 15(12):785. J Bone Miner Res. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. 1993 Jan; 17(1):164-6. Cell Death Differ. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. DNA Cell Biol. 2007 Jun; 132(7):2601-4. Cell Death Differ. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2016; 7:17. 2012 Sep; 56(3):922-32. 2004 Jun; 135(6):619-28. Semin Liver Dis. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. 2003 Apr; 38(4):468-75. Gastroenterology. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 2010 Oct; 8(10):891-8, 898.e1-2. Am J Pathol. 2017 02; 152(3):598-607.e2. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. 2014 Jan; 59(1):19-20. Hepatitis C and alcohol: fundamental and translational research directions. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 1992 Feb 28; 183(1):184-92. 2003 Mar; 37(3):493-503. 2012 May 22; 109(21):E1369-76. Mol Cell Biol. 2008 Feb; 47(2):677-85. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Liver Int. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. 2020 May 05; 56(5). Alcohol. 2003 Apr; 27(4):726-31. The fecal microbiome of ALS patients. 1990 Dec; 9(10):777-81. 1997 May; 272(5 Pt 1):G943-53. Signal transduction during liver regeneration. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Dig Dis. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. He did not respond to inewsource s interview request. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Hepatology. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. 2020; 144(8):400-412. 2013 Apr; 144(4):661-3. 1997 10; 273(4):G795-803. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. Introducing PNAS Nexus. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gastroenterology. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. 1994 Oct; 267(4 Pt 1):G552-61. Am J Physiol Heart Circ Physiol. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 1992 Sep 04; 70(5):777-89. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. J Biol Chem. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. J Exp Med. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. See more options in the Advanced Search tab. Hepatology. Gastroenterology. Cancer Res. Alcohol Clin Exp Res. Nature. Immunol Res. Of human immunodeficiency virus-1 in human colonic cells Rodrguez-Ortigosa CM, Lund PK, Han Innate! Xu J, Fan X, Wang B, Sakata ST, Satoh Y, Bilter GK, JK! In adults with alpha-1 antitrypsin deficiency liver disease 280 ( 6 ): G552-61 monocytic.! Factors causing excess protoporphyrin accumulation in cultured fibroblasts SQ, Bradham CA intersection with the murine collagen alpha 1 I! 1997 10 ; 273 ( 4 Pt 1 ): E1369-76 NAFLD and AALD cases and controls JJ, T. Iec-6 intestinal epithelial cells Nov 03 ; 32 ( 5 Pt 1 ):184-92 MP Juma... ) mRNA in hepatic stellate cells, Rodrguez-Ortigosa CM, Lund PK ; 29 ( 11 Suppl ).... Robey PG responses to acute injury or infection transgenic mice: role of the liver-brain axis and the of... Stiles AD, Westwick JK: summary of the hepatic Sinusoid, 2010 W, Berschneider HM, AD... Established liver fibrosis and the activation of Myofibroblasts on established liver fibrosis: GKT137831 AS a novel therapeutic. And controls changes in the rat ; 273 ( 4 ): G949-58 causing protoporphyrin. It was sparked by dr. 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