Lifestyle changes like exercising and eating more fruits and veggies may help with hot flashes. In fact, this was a common side effect in studies of letrozole. Like most drugs, letrozole oral tablets may cause mild or serious side effects. These act as chemical messengers and help control the activity of cells and organs. blistering, crusting, irritation, itching, or reddening of the skin, holding false beliefs that cannot be changed by fact, seeing, hearing, or feeling things that are not there. Some people benefit from switching to a different hormone therapy. This drug works by decreasing the amount of the hormone estrogen in your body. These medications work by stimulating your body's immune system. Letrozole [package insert]. Mild side effects of letrozole oral tablets that have been reported include: hot flashes feeling weak or having increased tiredness dizziness belly pain or cramping hair loss swelling, usually in. Certain pharmacies provide medication labels that: Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesnt. Like any drug,letrozolecan cause side effects. Summary: Urinary tract infection is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. Here are a few questions you may want to ask: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. Medically reviewed by Drugs.com on May 4, 2022. Femara is available in generic form. Their risk is higher because of the cancer itself and some treatments for breast cancer. Letrozole can interact with tamoxifen. Letrozole can cause high blood pressure (hypertension) in some people. When taken for infertility, its usually only used for a few days per menstrual cycle. The tablets come in one strength: 2.5 milligrams (mg). But it can still happen. Additionally, you can find information about weight management here. Do not take two doses at one time. Lifestyle changes suggested for relieving hot flashes could also help with night sweats. 2023 eHealthMe.com. To learn about other mild side effects, talk with your doctor or pharmacist, or read letrozole oral tablets prescribing information. 3. Use the medicine exactly as directed. These websites also offer tools to help you find low-cost healthcare and certain educational resources. Brisk walking can also be beneficial. Before using anti-inflammatory pain relief, ask your doctor about the correct dose, how long you should use it for and any possible side effects, especially if you have a stomach ulcer or asthma. They can tell you if its safe for you to take the medication with letrozole. Pharmaceutical Society of Australia "APPGuide online. (2014). Although not all of these side effects may occur, if they do occur they may need medical attention. Other symptoms may include shortness of breath, sweating, or indigestion. Female hormones that occur naturally in the body can increase the growth of some breast cancers. Call your doctor for medical advice about side effects. American Cancer Society. Find out more about hair loss and thinning. Letrozole is usually taken for 5 years, may be recommended for up to 10 years depending on your individual circumstances. They may recommend ways to help reduce the pain. With breast cancer, cancer cells in your breast grow quickly and out of control. 1. But your doctor will recommend if its something you should do. If these affect your jaw, its possible the pain could spread and feel like tooth pain. If you have a certain type of breast cancer, your doctor may prescribe letrozole for you. Talk with your doctor if you have questions about taking this drug for breast cancer. Version: 8.02. Redness and swelling of your vagina and vulva. About 10% of people had muscle pain. letrozole is for use only in women who can no longer get pregnant. During studies of letrozole, headaches were a common side effect in people taking the drug. O 0. These side effects can often be managed with lifestyle changes. You should also talk with your doctor if youre breastfeeding or considering it. Other side effects may take longer to develop because they require a build-up of the drug in your body. Mild side effects of many drugs may go away within a few days or a couple of weeks. How Letrozole Is Given: Letrozole is a pill, taken by mouth. More than 10% of people experienced nausea in letrozoles clinical trials for breast cancer. Cancer-related fatigue is extreme tiredness that doesnt go away with rest or sleep. Common letrozole side effects include hot flashes, night sweats, and muscle or joint pain. Added to Saved items. Continue reading. How to Reduce Your Risk of Breast Cancer: 10 Lifestyle Recommendations, Symptoms of Late Stage Metastatic Breast Cancer, What to Know and Consider Before Having Prophylactic Mastectomy. You may feel like your heart is racing (heart palpitations) when taking letrozole, which is more common in older people. Medically reviewed by Drugs.com. To learn about the cancers letrozole treats, see the What is letrozole used for? section above. Letrozole works by blocking the action of the enzyme aromatase, which prevents the body from converting androgens into estrogens. If you have been given bisphosphonates (see below) as part of your treatment you will not need a scan. This is when part of the blood clot breaks away and travels to the lung. These drugs include: This list doesnt contain all types of drugs that may interact with letrozole oral tablets. Phytoestrogens act like estrogen in the body. This withdrawal response isnt the same as withdrawal that happens when your body becomes dependent on a drug and stopping the drug causes symptoms. If these side effects become too bothersome, talk to your healthcare provider about other options. You may have some hair loss or thinning while taking letrozole. Different individuals may respond to medication in different ways. It is created by eHealthMe based on reports of 39,784 people who have side effects when taking Letrozole from the FDA, and is updated regularly. Letrozole can sometimes cause headaches. Australian prescription products guide online. Letrozole is an oral medication known as an aromatase inhibitor. If you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room. It is also used for women who have already had other cancer treatments (eg, tamoxifen). However, for some people they may cause distress and disrupt everyday life. However, the ovarian follicle's response to FSH is only a part of the endocrine events occurring in a developing follicle. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. Dizziness Letrozole may cause dizziness. 4. These symptoms usually improve or become easier to manage over time. The use of the eHealthMe site and its content is at your own risk. To make ovulation happen at the right time in your menstrual cycle, youll take letrozole for a few days after the start of your period. Some people also experience chest pain. High levels in liver disease: Letrozole is broken down by liver enzymes. Went to a urogyn who said this is a result of the tissues thinning from lack of estrogen. Because letrozole lowers estrogen levels, it can cause bone loss as a side effect. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. But, before starting any new medications, be sure to talk with your doctor or pharmacists. Sold under the brand name Femara, letrozole was originally created to treat breast cancer. Serious side effects from letrozole oral tablets can occur, but they arent common. The active ingredient in OXYTROL, oxybutynin, can cause swelling around the eyes, lips, genitals, hands or feet. Lowering your level of estrogen helps stop your breast cancer from growing. Sometimes your immune system can attack normal, noncancerous parts of your body, such as your colon (colitis). Letrozole can sometimes cause headaches. The American Society of Clinical Oncology (ASCO) recommends that 10 years should be the maximum duration of therapy, based on their 2019 clinical practice guideline update. Some studies show that turmeric may help fight infections and some cancers. This includes cancer cells. For instance, if you have hot flashes or nausea with letrozole, you can try reducing the amount of spicy or rich foods you eat. Spot the signs and symptoms of secondary breast cancer, 1. If you drink alcohol while youre taking letrozole, you might be more likely to have certain side effects, including: If you plan to drink alcohol while youre taking letrozole, make sure to talk with your doctor. But sometimes, metformin is given together with clomiphene to help treat infertility in females with PCOS. Breast Cancer Now is a company limited by guarantee registered in England (9347608) and a charity registered in England and Wales (1160558), Scotland (SC045584) and Isle of Man (1200). Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. When used for infertility, about 22% of people reported feeling tired. Serious side effects of letrozole oral tablets that have been reported include: Letrozole starts working right away in your body after you begin taking it. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. To understand diagnoses, you should understand breast cancer staging and what each means for overall outlook. eHealthMe is studying from 40,330 Letrozole users for its effectiveness, alternative drugs and more. If the bleeding continues for more than a few days, tell your specialist. But if the liver isnt working properly, it may cause a build up of medication in the body. You may report side effects to FDA at 1-800-FDA-1088. While there are some natural supplements available over the counter to treat hot flashes, these arent recommended in this case. Letrozole oral tablets are a generic drug, which means theyre an exact copy of the active drug in a brand-name medication. , 7 , ? GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Some people find letrozole produced by one manufacturer seems to suit them better than another. Common letrozole side effects include hot flashes and night sweats. For information about the difference between sex and gender, see this article. This bone loss may cause joint pain. We comply with the HONcode standard for trustworthy health information. Avoid alcohol as it may make you feel more tired and drowsy. (2009). These symptoms can include: An itchy or burning sensation in your vagina and vulva. It doesnt matter when you take letrozole, as long as you take it at the same time every day. They can also answer other questions related to using this drug for infertility. If you have questions about taking letrozole with other drugs, talk with your doctor. 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