J.Nutr. View abstract. Martin, K. R., Failla, M. L., and Smith, J. C., Jr. Beta-carotene and lutein protect HepG2 human liver cells against oxidant-induced damage. 2007;125(9):1225-1232. Lutein is an orange-colored nutrient. Ge XX, Xing MY, Yu LF, et al. A case-control study. Foods Int.J.Cancer 9-1-2012;131(5):1158-1168. 2005 - 2023 WebMD LLC. View abstract. Flood V, Smith W, Wang JJ, et al. Aside from protecting eyes, lutein uses also include helping prevent skin disorders, several types of cancer including colon or breast cancer, type 2 diabetes, and risk factors associated with coronary heart disease. Bartlett, H. E. and Eperjesi, F. Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial. Lutein vitamin is considered a natural treatment for macular degeneration symptoms (AMD), which is considered the most common cause of blindness among older adults. View abstract. Majumdar SK, Shaw GK, Thomson AD, et al. Eur.J.Clin.Nutr. 2002;74(3):371-381. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. The possible significance of parallel changes in plasma lutein and retinol in Pakistani infants during the summer season. When we eat foods high in lutein or take it in supplement form, its believed to be pretty easily transported around the body, especially to the parts of the eyes called the macula and the lens. Roodenburg AJ, Leenen R, van het Hof KH, et al. View abstract. Dietary intake of antioxidants and risk of age-related macular degeneration. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. J Nutr 2022;152(11):2555-64. J Nutr 1997;127:1636S-45S. Siems, W. G., Sommerburg, O., and van Kuijk, F. J. Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. Effect of long-chain ?-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. Xu J, Song C, Song X, Zhang X, Li X. Carotenoids and risk of fracture: a meta-analysis of observational studies. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. 1996;126(9):2098-2106. View abstract. Some might have a harder time utilizing it and other antioxidants from foods and transporting to tissues within the eyes or other organs. J.Matern.Fetal Neonatal Med. Molecules. Zhang Y, Knol LL, Tan L. Association between dietary lutein/zeaxanthin intake and metabolic syndrome among US females: An analysis of national health and examination surveys 2015-2018. JAMA Intern Med. Ophthalmic Res. Antioxidant status and neovascular age-related macular degeneration. Am.J.Clin.Nutr. BMJ 1992;305:335-9. Wang X, Jiang C, Zhang Y, et al. Eur.J.Clin.Nutr. View abstract. Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., and Morganti, P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. According to the Centers for Disease Control and Prevention (CDC), Americans get American Macular Degeneration Association, Top 7 Ways Carrot & Carrot Juice Benefit Your Body, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Is Lamb Healthy? View abstract. 2012;107(3):350-359. View abstract. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. View abstract. WebLutein is one of two major carotenoids found in the human eye (macula and retina). 2010;26(6):623-626. SanGiovanni, J. P. and Neuringer, M. The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field. (Tokyo) 2009;55(6):479-485. Johnson, E. J., McDonald, K., Caldarella, S. M., Chung, H. Y., Troen, A. M., and Snodderly, D. M. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Schalch, W., Cohn, W., Barker, F. M., Kopcke, W., Mellerio, J., Bird, A. C., Robson, A. G., Fitzke, F. F., and van Kuijk, F. J. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity. Ma, L., Yan, S. F., Huang, Y. M., Lu, X. R., Qian, F., Pang, H. L., Xu, X. R., Zou, Z. Y., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., Dou, H. L., and Lin, X. M. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. Tanaka, T., Shnimizu, M., and Moriwaki, H. Cancer chemoprevention by carotenoids. BMJ Open 2022;12(6):e052320. Med.Sci.Sports Exerc. View abstract. They are related to other carotenoids, such as beta-carotene andlycopene. View abstract. Int J Vitam.Nutr Res. Malila, N., Virtamo, J., Virtanen, M., Pietinen, P., Albanes, D., and Teppo, L. Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. Acta Ophthalmol. Breast Cancer Res.Treat. 26th ed. J Aging Res 2019;2019:3709402. View abstract. 2012;56(1):126-146. View abstract. Just one drop of this thick cream will moisturize dry hands or itchy eczema spots. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). Cancer Causes Control 1991;2:325-57. 2011;82(11):667-680. 10-10-2003;2:12. Am J Clin Nutr 2005;82:88-97. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). View abstract. JAMA 1994;272:1413-20. 2013 Jan;30(1):25-32. Chen F, Hu J, Liu P, Li J, Wei Z, Liu P. Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies. Albanes D, Virtamo J, Taylor PR, et al. Br J Nutr 2021;126(7):1028-1039. View abstract. View abstract. Note that the numbers in parentheses (1, 2, etc.) In fact, eye vitamins with lutein are some of the bestvitamins for macular degeneration. View abstract. This information may not fit your specific health circumstances. Nutrition 2003;19(1):21-24. Lopresti AL, Smith SJ, Drummond PD. A multicenter randomized controlled study of antioxidant supplementation with lutein for chronic central serous chorioretinopathy. View abstract. Thurmann PA, Schalch W, Aebischer JC, et al. Glabska D, Guzek D, Zakrzewska P, Lech G. Intake of Lutein and Zeaxanthin as a Possible Factor Influencing Gastrointestinal Symptoms in Caucasian Individuals with Ulcerative Colitis in Remission Phase. Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies. 1999;19(6):491-495. Chew EY, SanGiovanni JP, Ferris FL, et al. Effects of supplemental beta-carotene , cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. 2010;21(6):544-549. Ophthalmic Surg Lasers Imaging Retina 2016;47(6):528-35. 1995;36(12):2531-2541. Tan AC, Balaratnasingam C, Yannuzzi LA. JAMA Ophthalmol 2015;133(12):1415-24. A meta-analysis. A one year study of the macular pigment: the effect of 140 days of a lutein supplement. Am J Clin Nutr 2008;87(5):1521-1529. View abstract. Hammond, B. R., Jr., Fuld, K., and Curran-Celentano, J. Macular pigment density in monozygotic twins. View abstract. Am.J.Clin.Nutr. WebCommon drugs people take besides Lutein *: Dupixent: 2 people, 18.18%. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. Vegetables, fruit, and cancer. View abstract. Paetau, I., Rao, D., Wiley, E. R., Brown, E. D., and Clevidence, B. VandenLangenberg GM, Mares-Perlman JA, Klein R, et al. View abstract. View abstract. View abstract. Steinmetz KA, Potter JD. View abstract. Slattery ML, Benson J, Curtin K, et al. Biomed Res 2011;32(6):387-393. Vojnikovic, B., Kovacevic, D., Njiric, S., and Coklo, M. Long term results of age-related macular degeneration therapy with prednisolone acetate--special refer to peripheral visual field changes. Coll.Antropol. Background: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy. WebLutein & Zeaxanthin Eye Health Supplement for Adults - Delicious Vegan Eye Vitamins Lutein and Zeaxanthin Gummies - Zeaxanthin Plus Lutein 20mg for Vision Clarity Dry Eye Relief and Blue Light Support. Koonsvitsky BP, Berry DA, et al. View abstract. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Some observational studies show that xanthophyll carotenoids, including lutein, can help reduce the risk of developing heart disease and stroke. View abstract. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: Results from NHANES. Zhang PC, Wu CR, Wang ZL, Wang LY, Han Y, Sun SL, et al. Zhang W, Li W, Du J. An ancillary study of the women's health initiative. Cancer Epidemiol.Biomarkers Prev. Sasamoto, Y., Gomi, F., Sawa, M., Tsujikawa, M., and Nishida, K. Effect of 1-year lutein supplementation on macular pigment optical density and visual function. View abstract. Arch.Ophthalmol. Sadly, the incidence of AMD is expected to triple by 2025, according to the American Optometric Association. View abstract. Am J Clin Nutr 1997;66:366-72. Atherosclerosis Risk in Communities. 2013;54(3):1781-1788. View abstract. Invest Ophthalmol.Vis.Sci. Cardinault, N., Tyssandier, V., Grolier, P., Winklhofer-Roob, B. M., Ribalta, J., Bouteloup-Demange, C., Rock, E., and Borel, P. Comparison of the postprandial chylomicron carotenoid responses in young and older subjects. Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study. The highest amount of dietary lutein is found in leafy green vegetables, such as: kale spinach broccoli lettuce parsley basil leeks peas Lutein can also be found in other Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. Cancer Epidemiol.Biomarkers Prev. Lutein supplements have been used safely by adults in doses up to 15 to 20 milligrams daily for as long as two years without any serious side effects. Am J Clin Nutr 2003;78(5):985-992. View abstract. Spread supplemented with moderate doses of vitamin E and carotenoids reduces lipid peroxidation in healthy, nonsmoking adults. J.Matern.Fetal Neonatal Med. Arch.Ophthalmol. View abstract. Ophthalmology 2011;118(10):1958-1965. Bernstein, P. S., Ahmed, F., Liu, A., Allman, S., Sheng, X., Sharifzadeh, M., Ermakov, I., and Gellermann, W. Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center. Invest Ophthalmol.Vis.Sci. Olmedilla, B., Granado, F., Southon, S., Wright, A. J., Blanco, I., Gil-Martinez, E., Berg, H., Corridan, B., Roussel, A. M., Chopra, M., and Thurnham, D. I. Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries. Parisi V, Tedeschi M, Gallinaro G, et al. Acta Ophthalmol Scand 1997;75:634-40. Long-term Outcomes of Adding Lutein/Zeaxanthin and ?-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. The same goes for eating foods that naturally contain this carotenoid try pairing things like squash, carrots or eggs with healthy sources of fats, including nuts, coconut, olive oil or avocado, to boost their effectiveness. Int J Food Sci Nutr 2016;67(7):744-53. Clin Sci (Lond) 2002;102:447-56. 2008;32(2):351-353. View abstract. View abstract. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Sedating antihistamines are also called first-generation antihistamines because they were the first 2014;42(1):25-38. View abstract. View abstract. View abstract. Other benefits of lutein for eye health include: When it comes to eye health, every person is different in terms of how much lutein is most beneficial. 2014 Jan;252(1):63-70. Moeller, S. M., Parekh, N., Tinker, L., Ritenbaugh, C., Blodi, B., Wallace, R. B., and Mares, J. USCs observational studies show that people with the highest levels of lutein in the blood experience less plaque buildup in the arteries, while the opposite is also true: The fewer lutein-rich plant foods someone eats, the more clogged their arteries seem to become. You already know that filling up on plenty of fruits and veggies is good for you, and heres just another example of why that is. Wilson LM, Tharmarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA. Clin.Nutr. A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses. Ophthalmology 2012;119(11):2290-2297. View abstract. Diabetes Care 2022;45(6):1453-1461. JAMA Ophthalmol. Am J Clin Nutr 1995;62:1448S-61S.. View abstract. View abstract. Sin, H. P., Liu, D. T., and Lam, D. S. Lifestyle modification, nutritional and vitamins supplements for age-related macular degeneration. Taking care of sensitive skin is the first step in treating For people with a genetic predisposition to eye disorders or cancer, taking more lutein might be necessary. Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies. View abstract. A. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. View abstract. Arch.Ophthalmol. Exp.Eye Res. It's related to beta-carotene and vitamin A. Lutein-rich foods include egg yolks, broccoli, spinach, kale, corn, orange pepper, kiwi fruit, grapes, orange juice, zucchini and squash. Bone, R. A., Landrum, J. T., Mayne, S. T., Gomez, C. M., Tibor, S. E., and Twaroska, E. E. Macular pigment in donor eyes with and without AMD: a case-control study. Curr.Pharm.Des 2012;18(34):5577-5589. J Epidemiol. Invest Ophthalmol.Vis.Sci. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli, Brussels sprouts, eggs, oranges, and papaya. View abstract. Kostic D, White WS, Olson JA. 3-1-2001;153(5):424-432. View abstract. Arch Ophthalmol 1993;111:761-72. That is exactly why the lens needs to remain clear and free from the cloudiness that is indicative of cataracts. Dietary lutein and zeaxanthin are associated with working memory in an older population. View abstract. Am J Clin Nutr 1999;70:517-24. View abstract. Cota F, Costa S, Giannantonio C, Purcaro V, Catenazzi P, Vento G. Lutein supplementation and retinopathy of prematurity: a meta-analysis. View abstract. B. Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. View abstract. View abstract. A., and Guymer, R. H. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. Schweiggert, R. M., Mezger, D., Schimpf, F., Steingass, C. B., and Carle, R. Influence of chromoplast morphology on carotenoid bioaccessibility of carrot, mango, papaya, and tomato. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. Am J Epidemiol 2007;165(3):246-55. Furosemide: 2 people, Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses. 2012;131(1):239-253. Invest Ophthalmol.Vis.Sci. Manzoni P, Guardione R, Bonetti P, et al. There arent any known special precautions for women who are pregnant or breastfeeding, but its always a good idea to speak with your doctor when pregnant before beginning new supplemental treatments. 2009;102(2):186-190. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. 2012;70(4):234-240. PLoS One 2019;14(12):e0227048. View abstract. Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. 2004;80(1):131-136. Nutrients 2020;12(2):274. Lyle BJ, Mares-Perlman JA, Klein BE, et al. Calendula is often marketed as a treatment for eczema and dermatitis, but there is not much research supporting its effectiveness for these conditions. Berendschot, T. T., Broekmans, W. M., Klopping-Ketelaars, I. Mares-Perlman JA, Brady WE, Klein R, et al. Nolan JM, Power R, Howard AN, et al. Lutein and zeaxanthin intake during pregnancy and visual function in offspring at 11-12 years of age. Nutr Cancer 1998;32(3):154-158. J Nutr 2004;134:1887-93. Curr Dev Nutr 2021;5(10):nzab123. The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Plasma antioxidant vitamins and carotenoids and age-related cataract. Stedman's Medical Dictionary. View abstract. Medicine (Baltimore) 2019;98(29):e15404. Graefes Arch.Clin.Exp.Ophthalmol. Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. Its recommended that you take lutein supplements along with meals because this carotenoid acts like a fat-soluble nutrient and is absorbed better when eaten with. View abstract. A., Klein, M. L., Gehrs, K. M., Johnson, E. J., Snodderly, D. M., Wallace, R. B., Chappell, R. J., Parekh, N., Ritenbaugh, C., and Mares, J. View abstract. Lutein is an antioxidant often used in the treatment or prevention of eye diseases. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. View abstract. 2006;84(5):971-974. View abstract. 2000;46(11):1818-1829. View abstract. 2012;17(3):3202-3242. Lutein, zeaxanthin and meso-zeaxanthin supplementation associated with macular pigment optical density. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. As another example, one group of people who can usually afford to take more is those with cystic fibrosis. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Lutein has no known severe, serious, moderate, or mild interactions with other drugs. This information does not contain all possible interactions or adverse effects. Glucosamine: 2 people, 18.18%. J.Nutr. In particular, lutein is known to improve or even prevent age-related macular disease which is the leading cause of blindness and vision impairment. 2002;120(12):1732-1737. Carcinogenesis 1997;18(9):1847-1850. View abstract. Romagnoli, C., Giannantonio, C., Cota, F., Papacci, P., Vento, G., Valente, E., Purcaro, V., and Costa, S. A prospective, randomized, double blind study comparing lutein to placebo for reducing occurrence and severity of retinopathy of prematurity. View abstract. Med Hypotheses 1983;12:239-51. Garcia-Closas, R., Agudo, A., Gonzalez, C. A., and Riboli, E. Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. Supplementation with carotenoids, omega-3 fatty acids, and vitamin E has a positive effect on the symptoms and progression of Alzheimer's disease. Cancer Sci. Ophthalmol Ther 2022;11(4):1463-1477. J Lab Clin Med 1999;134(6):592-598. This daily supplementation decreased the risk of macular degeneration from intermediate to advanced stages by 25%. View abstract. Keep in mind that as with other antioxidants, people seem to differ in terms of how capable their bodies are of absorbing lutein. Broekmans, W. M., Berendschot, T. T., Klopping-Ketelaars, I. Lutein and its relative zeaxanthin are pigments called carotenoids. J Matern Fetal Neonatal Med 2020:1-6. Berson EL, Rosner B, Sandberg MA, et al. Bartlett, H., Howells, O., and Eperjesi, F. The role of macular pigment assessment in clinical practice: a review. Loughman, J., Nolan, J. M., Howard, A. N., Connolly, E., Meagher, K., and Beatty, S. The impact of macular pigment augmentation on visual performance using different carotenoid formulations. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. Hammond, B. R., Jr., Curran-Celentano, J., Judd, S., Fuld, K., Krinsky, N. I., Wooten, B. R., and Snodderly, D. M. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. : AREDS2 Report 28 Ophthalmol 2015 ; 133 ( 12 ):.... 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